:root{--color-primary: #1a7c5a;--color-primary-light: #e8f5ef;--color-secondary: #2c5282;--color-accent: #d69e2e;--color-danger: #c53030;--color-gray: #718096;--color-bg: #f7fafc;--color-card: #ffffff;--color-border: #e2e8f0;--color-text: #2d3748;--color-text-light: #718096;--radius: 8px;--shadow: 0 2px 8px rgba(0,0,0,.08);--transition: .18s ease}*{box-sizing:border-box;margin:0;padding:0}body{font-family:Segoe UI,system-ui,-apple-system,sans-serif;background:var(--color-bg);color:var(--color-text);font-size:15px;line-height:1.6}[dir=rtl] body{font-family:Segoe UI,Noto Sans Arabic,system-ui,sans-serif}a{color:var(--color-primary);text-decoration:none}a:hover{text-decoration:underline}.app{display:flex;flex-direction:column;min-height:100vh}.main-content{flex:1;max-width:1200px;width:100%;margin:0 auto;padding:24px 20px}.navbar{display:flex;align-items:center;gap:16px;background:var(--color-card);border-bottom:2px solid var(--color-primary);padding:0 24px;height:56px;position:sticky;top:0;z-index:100;box-shadow:0 2px 6px #0000000f}.nav-brand{display:flex;align-items:center;gap:8px;text-decoration:none;cursor:pointer}.nav-tabs{display:flex;gap:2px;flex:1;margin:0 16px}.nav-tab{background:none;border:none;padding:8px 14px;border-radius:var(--radius);cursor:pointer;font-size:14px;color:var(--color-text-light);font-weight:500;transition:var(--transition);white-space:nowrap}.nav-tab:hover{background:var(--color-primary-light);color:var(--color-primary)}.nav-tab.active{background:var(--color-primary);color:#fff}.nav-right{display:flex;align-items:center;gap:10px;margin-left:auto}.lang-switcher{background:var(--color-border);border:none;padding:6px 12px;border-radius:var(--radius);cursor:pointer;font-weight:600;font-size:14px;color:var(--color-text);transition:var(--transition)}.lang-switcher:hover{background:var(--color-primary);color:#fff}.download-all-btn{background:var(--color-primary-light);color:var(--color-primary);border:1px solid var(--color-primary);padding:6px 12px;border-radius:var(--radius);font-size:13px;font-weight:600;white-space:nowrap;transition:var(--transition)}.download-all-btn:hover{background:var(--color-primary);color:#fff;text-decoration:none}.search-panel{background:var(--color-card);border-radius:var(--radius);padding:28px;box-shadow:var(--shadow)}.search-panel h2{font-size:22px;font-weight:700;color:var(--color-primary);margin-bottom:20px}.form-group{margin-bottom:16px}.form-group label{display:block;margin-bottom:6px;font-weight:500;font-size:14px;color:var(--color-text)}.form-group.inline{display:flex;gap:10px;align-items:center}.text-input{width:100%;padding:9px 12px;border:1px solid var(--color-border);border-radius:var(--radius);font-size:14px;transition:var(--transition);background:#fff;color:var(--color-text)}.text-input:focus{outline:none;border-color:var(--color-primary);box-shadow:0 0 0 3px #1a7c5a1f}.search-options{display:flex;flex-wrap:wrap;gap:16px 24px;margin-bottom:16px;padding:16px;background:var(--color-bg);border-radius:var(--radius)}.search-options .form-group{margin-bottom:0}.search-options select{padding:6px 10px;border:1px solid var(--color-border);border-radius:var(--radius);font-size:14px;background:#fff;color:var(--color-text)}select option{color:var(--color-text);background:#fff;font-family:inherit}.search-actions{display:flex;gap:10px;margin-top:8px}.btn-primary{background:var(--color-primary);color:#fff;border:none;padding:9px 20px;border-radius:var(--radius);font-size:14px;font-weight:600;cursor:pointer;transition:var(--transition);text-decoration:none;display:inline-flex;align-items:center}.btn-primary:hover{background:#155f45;text-decoration:none}.btn-primary:disabled{background:var(--color-gray);cursor:not-allowed}.btn-secondary{background:#fff;color:var(--color-text);border:1px solid var(--color-border);padding:9px 20px;border-radius:var(--radius);font-size:14px;font-weight:600;cursor:pointer;transition:var(--transition)}.btn-secondary:hover{border-color:var(--color-primary);color:var(--color-primary)}.back-btn{background:none;border:none;color:var(--color-primary);cursor:pointer;font-size:14px;margin-bottom:16px;padding:0}.back-btn:hover{text-decoration:underline}.hpo-select{margin-top:4px}.results-table-wrapper{margin-top:24px;overflow-x:auto}.result-count{font-size:13px;color:var(--color-text-light);margin-bottom:8px}.results-table{width:100%;border-collapse:collapse;font-size:14px}.results-table th{background:var(--color-primary);color:#fff;padding:10px 12px;text-align:left;font-weight:600;font-size:13px;white-space:nowrap}[dir=rtl] .results-table th{text-align:right}.results-table td{padding:9px 12px;border-bottom:1px solid var(--color-border);vertical-align:middle}.results-table tr:hover td{background:var(--color-primary-light)}.case-link{font-weight:600;color:var(--color-primary)}.gene-link{font-weight:600;color:var(--color-secondary)}.gene-link.bold{font-size:16px}.disease-cell{max-width:300px;font-size:13px}.mono{font-family:SFMono-Regular,Consolas,monospace;font-size:12px}.links-cell{display:flex;gap:6px;flex-wrap:wrap}.download-link{font-size:18px;color:var(--color-primary);text-decoration:none;opacity:.7}.download-link:hover{opacity:1}.translation-sub{font-size:.85em;color:var(--color-text-light);font-style:italic;margin-left:4px}.info-icon{display:inline-flex;align-items:center;justify-content:center;width:14px;height:14px;border-radius:50%;background:var(--color-primary-light);color:var(--color-primary);font-size:10px;font-weight:700;cursor:help;transition:var(--transition);vertical-align:middle;margin-left:4px;border:1px solid var(--color-primary)}.info-icon:hover{background:var(--color-primary);color:#fff}.score-badge{display:inline-block;background:var(--color-primary);color:#fff;padding:2px 8px;border-radius:12px;font-size:12px;font-weight:700}.score-value{font-weight:600;color:var(--color-primary);font-size:.9em}.source-badge{display:inline-block;padding:2px 8px;border-radius:12px;font-size:11px;font-weight:700;letter-spacing:.3px;text-transform:uppercase}.badge-saudi{background:#c6f6d5;color:#22543d}.badge-ddd{background:#e2e8f0;color:#4a5568}.badge-literature{background:#e9d8fd;color:#44337a}.badge-clinvar{background:#bee3f8;color:#2a4365}.badge-unknown{background:#fed7d7;color:#742a2a}.acmg-badge{display:inline-block;padding:2px 8px;border-radius:4px;font-size:11px;font-weight:700}.acmg-pathogenic{background:#fed7d7;color:#742a2a}.acmg-likely-pathogenic{background:#feebc8;color:#7b341e}.acmg-uncertain-significance{background:#fefcbf;color:#744210}.acmg-likely-benign,.acmg-benign{background:#c6f6d5;color:#22543d}.novel-badge{background:#feebc8;color:#7b341e;padding:2px 8px;border-radius:4px;font-size:11px;font-weight:700}.ancestry-badge{display:inline-flex;align-items:center;gap:4px;background:#ebf8ff;color:#2c5282;padding:3px 10px;border-radius:12px;font-size:12px;font-weight:600}.tab-bar{display:flex;gap:4px;margin-bottom:16px;border-bottom:2px solid var(--color-border);padding-bottom:8px}.tab-btn{background:none;border:none;padding:7px 14px;border-radius:var(--radius);cursor:pointer;font-size:14px;color:var(--color-text-light);font-weight:500;transition:var(--transition)}.tab-btn:hover{background:var(--color-primary-light);color:var(--color-primary)}.tab-btn.active{background:var(--color-primary);color:#fff}.case-header{display:flex;align-items:center;gap:12px;flex-wrap:wrap;margin-bottom:24px}.case-header h2{font-size:22px;font-weight:700}.case-actions{margin-left:auto}.detail-section{background:var(--color-card);border:1px solid var(--color-border);border-radius:var(--radius);padding:20px;margin-bottom:16px}.detail-section h3{font-size:16px;font-weight:700;color:var(--color-primary);margin-bottom:12px;padding-bottom:8px;border-bottom:1px solid var(--color-border)}.prop-list{display:grid;grid-template-columns:160px 1fr;gap:6px 12px}.prop-list dt{font-weight:600;color:var(--color-text-light);font-size:13px;padding-top:2px}.prop-list dd{font-size:14px}.hpo-tags{display:flex;flex-wrap:wrap;gap:6px}.hpo-tag{display:inline-block;background:var(--color-primary-light);color:var(--color-primary);border:1px solid #9ae6c3;padding:3px 10px;border-radius:12px;font-size:12px;font-weight:600}.hpo-tag.excluded{background:#fff5f5;color:var(--color-danger);border-color:#feb2b2;text-decoration:line-through}.hpo-tag-wrapper{display:inline-flex;flex-direction:column;vertical-align:top}.hpo-tag-wrapper.hpo-expanded{display:flex;flex-basis:100%;margin-bottom:6px}.hpo-tag-chip{display:inline-flex;align-items:center;gap:3px;background:var(--color-primary-light);color:var(--color-primary);border:1px solid #9ae6c3;padding:3px 5px 3px 10px;border-radius:12px;font-size:12px;font-weight:600}.hpo-tag-chip a{color:inherit;text-decoration:none}.hpo-tag-chip a:hover{text-decoration:underline}.hpo-tag-chip.excluded{background:#fff5f5;color:var(--color-danger);border-color:#feb2b2;text-decoration:line-through}.hpo-info-btn{background:none;border:none;cursor:pointer;color:var(--color-primary);font-size:12px;padding:0 3px;line-height:1;opacity:.65;transition:opacity .15s;flex-shrink:0}.hpo-info-btn:hover{opacity:1}.hpo-tag-details{display:flex;flex-direction:column;gap:4px;margin-top:5px;padding:8px 12px;background:var(--color-card);border:1px solid var(--color-border);border-radius:var(--radius);font-size:13px;line-height:1.5;max-width:640px}.hpo-detail-row{display:flex;gap:6px;align-items:baseline}.hpo-detail-key{font-weight:600;color:var(--color-text-light);font-size:11px;text-transform:uppercase;letter-spacing:.4px;white-space:nowrap;flex-shrink:0}.hpo-detail-val{color:var(--color-text)}.hpo-lay{font-style:italic}.hpo-synonyms{color:var(--color-text-light);font-size:12px}.variant-card{border:1px solid var(--color-border);border-radius:var(--radius);padding:16px;margin-bottom:12px}.variant-header{display:flex;align-items:center;gap:10px;margin-bottom:12px}.variant-links{display:flex;flex-wrap:wrap;gap:8px;margin-top:12px}.ext-link{display:inline-block;background:#ebf8ff;color:#2c5282;border:1px solid #90cdf4;padding:3px 10px;border-radius:4px;font-size:12px;font-weight:600;transition:var(--transition)}.ext-link:hover{background:#2c5282;color:#fff;text-decoration:none}.togovar-link{background:#faf5ff;color:#553c9a;border-color:#d6bcfa}.togovar-link:hover{background:#553c9a;color:#fff}.gene-detail-card{background:var(--color-card);border:1px solid var(--color-border);border-radius:var(--radius);padding:24px;margin-top:16px}.gene-detail-card h3{font-size:24px;font-weight:700;color:var(--color-primary);margin-bottom:16px}.gene-links{display:flex;flex-wrap:wrap;gap:8px;margin-top:16px}.go-cell{font-size:13px;color:var(--color-text-light)}.gene-browser-layout{display:flex;gap:16px;align-items:flex-start}.gene-list-panel{width:240px;flex-shrink:0;background:var(--color-card);border:1px solid var(--color-border);border-radius:var(--radius);overflow:hidden;position:sticky;top:72px;max-height:calc(100vh - 90px);display:flex;flex-direction:column}.gene-list-filter{padding:10px;border-bottom:1px solid var(--color-border);flex-shrink:0}.gene-list-meta{padding:6px 14px;font-size:12px;color:var(--color-text-light);border-bottom:1px solid var(--color-border);flex-shrink:0}.gene-list-scroll{flex:1;overflow-y:auto}.gene-list-item{display:flex;justify-content:space-between;align-items:center;padding:7px 14px;cursor:pointer;font-size:13px;border-bottom:1px solid var(--color-border);transition:var(--transition)}.gene-list-item:hover{background:var(--color-primary-light)}.gene-list-item.active{background:var(--color-primary);color:#fff}.gene-list-item .gene-symbol{font-weight:600;font-family:SFMono-Regular,Consolas,monospace}.gene-list-item .gene-count{font-size:11px;color:var(--color-text-light);background:var(--color-border);padding:1px 7px;border-radius:10px;min-width:28px;text-align:center}.gene-list-item.active .gene-count{color:#ffffffd9;background:#fff3}.gene-detail-panel{flex:1;min-width:0}.gene-select-prompt{padding:60px 40px;text-align:center;color:var(--color-text-light);font-size:15px;background:var(--color-card);border:1px solid var(--color-border);border-radius:var(--radius)}.gene-source-toggles{display:flex;align-items:center;gap:18px;padding:10px 16px;background:var(--color-bg);border:1px solid var(--color-border);border-radius:var(--radius);margin:10px 0;font-size:14px}.toggle-label{display:flex;align-items:center;gap:5px;cursor:pointer;-webkit-user-select:none;user-select:none}.pub-link{font-size:11px;color:var(--color-text-light);border:1px solid var(--color-border);padding:2px 7px;border-radius:4px;font-weight:600;text-decoration:none;transition:var(--transition)}.pub-link:hover{border-color:var(--color-primary);color:var(--color-primary);text-decoration:none}@media(max-width:768px){.gene-browser-layout{flex-direction:column}.gene-list-panel{width:100%;position:static;max-height:280px}}.about-page{background:var(--color-card);border-radius:var(--radius);padding:36px;box-shadow:var(--shadow);max-width:800px}.about-page h1{font-size:28px;color:var(--color-primary);margin-bottom:8px}.about-page h2{font-size:18px;color:var(--color-text);margin:24px 0 8px;padding-bottom:4px;border-bottom:1px solid var(--color-border)}.about-page p{margin-bottom:12px;line-height:1.7}.about-page ul{margin:8px 0 12px 20px}.about-page li{margin-bottom:4px;line-height:1.6}.about-page blockquote{border-left:4px solid var(--color-primary);padding-left:16px;color:var(--color-text-light);margin:16px 0}.about-page code{background:#f0fff4;padding:2px 6px;border-radius:3px;font-family:monospace;font-size:13px}.loading{color:var(--color-text-light);font-style:italic;padding:20px 0}.error-msg{color:var(--color-danger);background:#fff5f5;padding:10px 14px;border-radius:var(--radius);margin-top:10px;font-size:14px}.footer{text-align:center;padding:16px;font-size:13px;color:var(--color-text-light);border-top:1px solid var(--color-border);margin-top:40px}.suggested-disease-block{border:1.5px dashed var(--color-accent);border-radius:var(--radius);padding:10px 14px;background:#fffbeb}.suggested-disease-mini{margin-top:4px;font-size:.85em;font-style:italic;color:#92400e;line-height:1.3}.suggested-label{display:block;font-style:italic;font-size:.82em;color:#92400e;margin-bottom:6px}.suggested-disease-list{list-style:none;padding:0;margin:0;display:flex;flex-direction:column;gap:4px}.suggested-disease-list li{font-style:italic;font-size:.95em;color:#78350f}.suggested-disease-list a{color:#92400e;font-style:italic;font-weight:600}.suggested-disease-list a:hover{text-decoration:underline}.suggested-id{font-size:.85em;color:var(--color-gray);font-style:normal}.suggested-gene{font-size:.82em;color:var(--color-gray);font-style:normal}.expression-chart-wrap{position:relative;overflow-x:auto;padding-bottom:4px}.expression-svg{display:block;min-width:0}.expression-tooltip{background:var(--color-text);color:#fff;padding:4px 10px;border-radius:4px;font-size:12px;white-space:nowrap;z-index:9999}.gene-diseases-section{margin-top:16px}.gene-diseases-section h4{font-size:14px;font-weight:600;color:var(--color-text-light);margin-bottom:8px;text-transform:uppercase;letter-spacing:.04em}.gene-disease-item{border:1px solid var(--color-border);border-radius:var(--radius);margin-bottom:6px;overflow:hidden}.gene-disease-header{display:flex;align-items:center;gap:8px;padding:8px 12px;background:var(--color-bg);flex-wrap:wrap}.gene-disease-toggle{background:none;border:none;cursor:pointer;font-size:11px;color:var(--color-text-light);padding:0;line-height:1}.gene-disease-label{font-weight:500;flex:1;min-width:0}.gene-disease-id{font-size:12px;color:var(--color-text-light);white-space:nowrap}.gene-disease-hpo{padding:8px 12px;background:var(--color-card);border-top:1px solid var(--color-border);display:flex;flex-wrap:wrap;gap:4px}.go-list{list-style:none;padding:0;margin:0;display:flex;flex-direction:column;gap:2px}.go-list li a{font-size:13px}.hpo-browser-layout{display:grid;grid-template-columns:320px 1fr;gap:0;height:calc(100vh - 140px);min-height:500px}.hpo-tree-panel{border-right:1px solid var(--color-border);display:flex;flex-direction:column;overflow:hidden}.hpo-tree-header{padding:12px 14px 8px;border-bottom:1px solid var(--color-border);background:var(--color-card);flex-shrink:0}.hpo-tree-header h3{font-size:14px;font-weight:600;margin-bottom:2px}.hpo-tree-hint{font-size:11px;color:var(--color-text-light)}.hpo-tree-scroll{flex:1;overflow-y:auto;overflow-x:hidden;padding:4px 0}.hpo-tree-node{-webkit-user-select:none;user-select:none}.hpo-tree-row{display:flex;align-items:center;gap:4px;padding-top:2px;padding-bottom:2px;cursor:pointer;transition:background var(--transition)}.hpo-tree-row:hover{background:var(--color-primary-light)}.hpo-tree-selected{background:var(--color-primary-light)!important;font-weight:600}.hpo-tree-toggle{background:none;border:none;cursor:pointer;font-size:10px;color:var(--color-text-light);width:18px;flex-shrink:0;padding:0;line-height:1}.hpo-tree-label{font-size:13px;flex:1;overflow:hidden;text-overflow:ellipsis;white-space:nowrap;cursor:pointer}.hpo-tree-count{font-size:11px;color:var(--color-primary);font-weight:600}.hpo-tree-id{font-size:10px;color:var(--color-text-light);flex-shrink:0;padding-right:8px}.hpo-detail-panel{overflow-y:auto;padding:16px 20px}.hpo-term-card{background:var(--color-card);border:1px solid var(--color-border);border-radius:var(--radius);padding:16px;margin-bottom:16px}.hpo-term-card h3{font-size:16px;font-weight:600;margin-bottom:8px}.hpo-term-id{font-size:13px;font-weight:400;color:var(--color-text-light)}.hpo-term-def{font-size:13px;color:var(--color-text-light);margin-bottom:8px;line-height:1.5}.hpo-term-lay{font-size:13px;color:var(--color-text-light);font-style:italic;margin-bottom:6px}.hpo-term-stats{font-size:13px;color:var(--color-text-light);margin-bottom:8px}.row-expand-btn{background:none;border:none;cursor:pointer;font-size:10px;color:var(--color-text-light);padding:2px 4px;border-radius:3px}.row-expand-btn:hover{background:var(--color-primary-light);color:var(--color-primary)}.variant-row-expanded>td{background:var(--color-primary-light)}.variant-detail-row>td{padding:0!important}.variant-detail-panel{background:#f0f7f4;border-bottom:2px solid var(--color-primary);padding:10px 16px;display:flex;flex-wrap:wrap;gap:12px 24px}.variant-detail-item{font-size:13px}.consequence-badge{display:inline-block;padding:1px 7px;border-radius:10px;font-size:12px;font-weight:500}.badge-high{background:#fed7d7;color:#c53030}.badge-moderate{background:#feebc8;color:#c05621}.badge-low{background:#c6f6d5;color:#276749}.phenotype-browser{display:flex;flex-direction:column;gap:16px}.pb-search-row{display:flex;align-items:center;gap:16px;flex-wrap:wrap}.pb-select-wrap{flex:1;min-width:280px}.pb-count{color:var(--color-text-light);font-size:14px}.pb-sections{display:flex;flex-direction:column;gap:24px}.pb-section h3{display:flex;align-items:center;gap:8px;font-size:15px;font-weight:600;margin-bottom:8px;color:var(--color-text)}.pb-hpo-count{color:var(--color-text-light);font-size:13px}.sparql-explorer{display:flex;flex-direction:column;gap:16px}.sparql-explorer h2{font-size:20px;font-weight:700}.sparql-hint{font-size:13px;color:var(--color-text-light)}.sparql-hint kbd{background:var(--color-border);border-radius:3px;padding:1px 5px;font-size:12px;font-family:monospace}.sparql-examples{display:flex;flex-wrap:wrap;gap:6px;align-items:center}.sparql-examples strong{font-size:13px;color:var(--color-text-light);margin-right:4px}.sparql-example-btn{background:var(--color-primary-light);border:1px solid var(--color-primary);color:var(--color-primary);border-radius:12px;padding:3px 12px;font-size:12px;cursor:pointer;transition:background var(--transition)}.sparql-example-btn:hover{background:var(--color-primary);color:#fff}.sparql-editor-wrap{display:flex;flex-direction:column;gap:8px}.sparql-editor{width:100%;font-family:Cascadia Code,Fira Code,JetBrains Mono,monospace;font-size:13px;line-height:1.5;padding:12px;border:1px solid var(--color-border);border-radius:var(--radius);background:#1e1e2e;color:#cdd6f4;resize:vertical;outline:none}.sparql-editor:focus{border-color:var(--color-primary)}.sparql-run-btn{align-self:flex-start;font-size:14px;padding:8px 20px}.sparql-endpoint-box{display:flex;flex-direction:column;gap:4px;background:var(--color-bg-secondary);border:1px solid var(--color-border);border-radius:var(--radius);padding:12px 16px;font-size:13px}.sparql-endpoint-label{font-weight:600;color:var(--color-text)}.sparql-endpoint-url{font-family:monospace;font-size:13px;color:var(--color-primary);word-break:break-all}.sparql-endpoint-hint{color:var(--color-text-light);font-size:12px;margin-top:4px}.sparql-curl-example{font-family:monospace;font-size:12px;color:var(--color-text-light);word-break:break-all}.sparql-results-header{display:flex;align-items:center;gap:12px;flex-wrap:wrap}.sparql-results-header .result-count{margin:0}.sparql-download-btns{display:flex;gap:8px}.sparql-dl-btn{background:var(--color-bg-secondary);border:1px solid var(--color-border);border-radius:var(--radius);padding:4px 12px;font-size:12px;cursor:pointer;color:var(--color-text);transition:background var(--transition)}.sparql-dl-btn:hover{background:var(--color-primary-light);border-color:var(--color-primary);color:var(--color-primary)}.sparql-results-table{font-size:13px}.sparql-uri{font-size:12px;word-break:break-all}[dir=rtl] .prop-list{direction:rtl}[dir=rtl] .tab-bar,[dir=rtl] .case-header{flex-direction:row-reverse}[dir=rtl] .case-actions{margin-left:0;margin-right:auto}[dir=rtl] .results-table th,[dir=rtl] .results-table td{text-align:right}[dir=rtl] .about-page blockquote{border-left:none;border-right:4px solid var(--color-primary);padding-left:0;padding-right:16px}[dir=rtl] .about-page ul{margin-left:0;margin-right:20px}@media(max-width:768px){.navbar{flex-wrap:wrap;height:auto;padding:8px 12px;gap:8px}.nav-tabs{order:3;width:100%;overflow-x:auto;padding-bottom:4px}.nav-tab{font-size:12px;padding:6px 10px}.main-content{padding:16px 12px}.search-panel{padding:16px}.prop-list{grid-template-columns:120px 1fr}.download-all-btn{display:none}}